Magaldrate simethicone syrup is a medication used to relieve symptoms of gastrointestinal discomfort, such as acid indigestion, heartburn, and gas. This antacid works by neutralizing stomach acid, while simethicone is an anti-gas agent that helps to break up gas bubbles in the digestive system. The combination of magaldrate and simethicone helps to relieve symptoms of bloating, gas, and heartburn. The magaldrate simethicone syrup is easy to take and is usually taken after meals and at bedtime. It may cause side effects, such as constipation, diarrhea, or stomach cramps.